Central to the differentiation and patterning of the Drosophila oocyte is the asymmetric intracellular localization of numerous mRNA and protein molecules involved in developmental signalling. Recent advances have identified some of the molecules mediating oocyte differentiation, specification of the anterior pole of the embryo, and determination of the embryonic germ line. This work is considered in the context of the classical model of the germ plasm as a cytoplasmic determinant for germ cell formation.

Specification of the anterior‐posterior axis of the Drosophila embryo is brought about by the asymmetric localization of specific maternally expressed RNAs and proteins within the oocyte. While many of these localized molecules have been identified and progress has been made towards understanding their functions, how the localization process is instigated remains unclear. A recent paper reports that protein kinase A (PKA) activity is essential for many of these RNA localizations and for the correct polarization of the microtubule cytoskeleton(1). These and (...) other results support a model for anterior‐posterior axis establishment which involves intercellular signalling between the oocyte and certain neighbouring somatic cells. (shrink)

What kind of thing are we? Paul Snowdon's answer is that we are animals, of a sort. This view--'animalism'--may seem obvious but on the whole philosophers have rejected it. Snowdon argues that animalism is a defensible way of thinking about ourselves. Its rejection rests on the tendency when doing philosophy to mistake fantasy for reality.

Fish proposes that we need to elucidate what 'disjunctivism' stands for, and he also proposes that it stands for the rejection of a principle about the nature of experience that he calls the decisiveness principle. The present paper argues that his first proposal is reasonable, but then argues, in Section II, that his positive suggestion does not draw the line between disjunctivism and non-disjunctivism in the right place. In Section III, it is argued that disjunctivism is a thesis about the (...) special nature of perceptual experience, and the thesis as elucidated here is then distinguished from and related to certain other ideas about perception, namely, direct realism and also McDowell's epistemological disjunctivism. (shrink)

The Pasadena game invented by Nover and Hájek raises a number of challenges for decision theory. The basic problem is how the game should be evaluated: it has no expectation and hence no well-defined value. Easwaran has shown that the Pasadena game does have a weak expectation, raising the possibility that we can eliminate the value gap by requiring agents to value gambles at their weak expectations. In this paper, I first prove a negative result: there are gambles like the (...) Pasadena game that do not even have a weak expectation. Hence, problematic value gaps remain even if decision theory is extended to take in weak expectations. There is a further challenge: the existence of a ‘value gap’ in the Pasadena game seems to make decision theory inapplicable in a number of cases where the right choice is obvious. The positive contribution of the paper is a theory of ‘relative utilities’, an extension of decision theory that lets us make comparative judgements even among gambles that have no well-defined value. (shrink)

The authors argue that the time is ripe for national and corporate leaders to move consciously towards the development of global ethics. This papers presents a model of global ethics, a rationale for the development of global ethics, and the implications of the model for research and practice.

Gift and gratitude are examined as moral realities and are found to play a variety of roles in the moral life and in moral discourse. Some of these have to do with obligations arising from the gift relation while others stand in some tension with the idea of obligation. The relation between these two kinds of elements is explored. Gift and gratitude are also examined in relation to moral agenthood. The analysis is then tested for its usefulness in relation to (...) some problematic gifts cited in Christian ethics. Finally, some normative implications of the analysis are briefly suggested. (shrink)

There are a number of concepts of common-sense morality, what one must do, what one ought to do, the supererogatory, the minimum that duty allows, the morally optional and the morally indifferent, that philosophers have been hard-pressed to represent in an integrated conceptual framework. Indeed, many philosophers have despaired at the attempt and concluded that only a fragment of these concepts belong to that fundamental sphere of morality that is the central focus of the ethicist. For example, the traditional scheme, (...) with its triad of the obligatory, the forbidden and the permissible, pigeonholes all actions into three mutually exclusive and exhaustive classes: those which are obligatory, those which are forbidden and those which are optional. Hence, at best, it can represent exactly two of the six aforementioned concepts. For from the standpoint of this scheme, what one must do and what one ought to do can't be distinguished and hence they can't both be represented. Although the morally optional can be represented, the supererogatory, one of its subclasses, cannot be represented. Furthermore, the morally indifferent, another subclass of the optional--one which is obviously disjoint from the supererogatory--cannot be represented. Finally, the minimum that duty allows finds no distinctive place in the traditional scheme. Thus, on the face of it, the traditional scheme is radically incomplete. ;I present, motivate and defend a new conceptual scheme for common-sense morality in which these concepts are represented and systematically integrated. An intuitively motivated semantic framework underpinning this conceptual scheme is also presented. Such a scheme, along with the associated semantic framework, is motivated by reflecting on the supererogationist's objections to utilitarianism and to the traditional scheme. But in addition, a new integrated network of linguistic motivations for this conceptual scheme is uncovered, one which is completely independent of supererogationistic considerations. Hence, these two separate sources of evidence for the centrality of this new scheme to our pre-theoretic thinking corroborate one another--thus jointly boosting the evidence beyond the mere sum of their separate evidential values. (shrink)

The ability to imagine hypothetical events in one’s personal future is thought to involve a number of constituent cognitive processes. We investigated the extent to which individual differences in working memory capacity contribute to facets of episodic future thought. College students completed simple and complex measures of working memory and were cued to recall autobiographical memories and imagine future autobiographical events consisting of varying levels of specificity . Consistent with previous findings, future thought was related to analogous measures of autobiographical (...) memory, likely reflecting overlapping cognitive factors supporting both past and future thought. Additionally, after controlling for autobiographical memory, residual working memory variance independently predicted future episodic specificity. We suggest that when imagining future events, working memory contributes to the construction of a single, coherent, future event depiction, but not to the retrieval or elaboration of event details. (shrink)

As transnational interactions increase, cross-cultural conflict concerning ethical issues is inevitable. This article presents a model for assisting decision makers in selecting appropriate strategies for addressing cross-cultural ethical conflict. A theoretical framework for the model is developed based on the literature on international business ethics and on conflict resolution. The model is illustrated through several case examples. Implications for future research and practice are discussed.

We should seek an ethic internal to marketing arising from marketing's societal function, rather than imposing some add-on ethic. This suggests that marketing should enhance the information and the freedom the potential customer brings to the market transaction. Defining and achieving this information and freedom is difficult, but marketers suggest that the market itself drives out major violators, a suggestion less persuasive concerning increasingly complex goods and services. Marketing also is tempted to appeal to our baser, darker side. These problems (...) are better addressed through self-regulation guided by a vision of advertising and business in the service of society, and by the marketer's own sense of integrity than through external regulation. (shrink)

Professor Donaldson in his book Corporations and Morality has attempted to use a social contract theory to develop moral principles for regulating corporate conduct. I argue in this paper that his attempt fails in large measure because what he refers to as a social contract theory is, in fact, a weak functionalist theory which provides no independent basis for evaluating business corporations. I further argue that given the nature of a morality based on contract and the nature of the modern (...) corporation, it is highly unlikely that any plausible contract theory of business ethics can be developed. (shrink)

Ein eben erschienenes Buch „Der Typenbegriff im Lichte der neuen Logik“ (von C. Hempel und P. Oppenheim) wird zum Anlass genommen, methodologische Probleme der Verwendung von Typenbegriffen zu diskutieren. Drei verschiedene Arten von Attributen werden unterschieden : klassifizierende Merkmale, abstufbare Merkmale und Massgrössen. Abstuf- bare Begriffe können standardisiert werden. So entstandene Standards werden als Quasi-Typen bezeichnet. Echte Typen entstehen aus Merkmalkombinationen. Diese Kombinationen werden in einem Merkmalsraum vorgenommen mit Hilfe sogenannter Reduktionen. Drei Arten von Reduktionen werden unterschieden. Die für die (...) empirische Sozialforschung wichtigste Reduktion ist die pragmatische : sie fasst Klassen von Merkmalkombinationen so zusammen, wie es ein vorliegendes Erhebungsproblem erfordert. Im allgemeinen werden Typen intuitiv gebildet, und erst nachher wird die ihnen entsprechende Merkmalskombination aufgedeckt. Dieses Verfahren heisst Substruktion. An Beispielen wird seine Bedeutung für die Praxis dargestellt. Es wird betont, dass die typologischen Operationen (Reduktion, Substruktion und Transformationen) nichts darüber aussagen, was ein Typus ist und wie er gefunden wird. Sie weisen nur gewisse formale Eigenschaften auf, die allen typologischen Systemen gemeinsam sind.Un livre récemment paru „Le concept de type à la lumière de la nouvelle logique“ (de C. Hempel et P. Oppenheim : „Der Typenbegriff im Lichte der neuen Logik“ ) fournit Toccasion de discuter quelques-uns des problèmes que pose l'emploi des concepts de type. On distingue trois catégories de caractères : caractères classificatoires, caractères gradués et mesures de grandeur. Les concepts gradués peuvent être standardisés de telle manière que naissent des standards que l'on peut qualifier de quasi-types. Les types authentiques naissent par combinaison de caractères. Ces combinaisons s'opèrent dans un „lieu de caractères“ (Merkmalsraum) à l'aide d'un procédé nommé réduction. On distingue trois sortes de réduction. La réduction la plus importante pour la recherche sociale est la réduction pragmatique : elle embrasse des classes de caractères combinés en fonction des exigences d'une enquête donnée. En général, les types sont formés intuitivement, ensuite seulement on découvre la combinaison de caractères correspondante. Cette démarche s'appelle substruction. On en montre la signification pour la pratique dans une série d’exemples. On souligne que les opérations typologiques (réduction, substruction, transformations) ne nous permettent nullement de dire ce qu'est un type et comment il a été découvert. Elles indiquent seulement certains caractères formels qui sont communs à tous les systèmes typologiques. (shrink)

This article argues that contemporary debates of the 'hard problem' of consciousness (i.e.how does 'mindless' matter produce 'matterless' mind?) cannot be resolved through philosophical analysis alone and need to be anchored to a comprehensive empirical foundation that includes psychophysiological research of psychosomatic phenomena and exceptional human experience. First, alternative perspectives on the mind–matter question and reasons why traditional formulations of the 'hard problem' have been so difficult to resolve are reviewed. Empirical evidence of mind modulation of bodily systems and its (...) implications for the classical quantitative–qualitative distinction and construct of causal closure are then considered. A novel theory that combines bottom-up (panpsychism) and top-down (non-theistic panenpsychism) approaches relating physical processes to mental activity is then proposed that has practical implications for conceiving and exploring alternatives to current ways of thinking about the mind–matter question. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:A "Hypostatic Union" of Two Practices but One Person?Paul F. KnitterThis is going to be an awkwardly personal reflection. But that, I understand, is what the assignment given to the members of the Society for Buddhist-Christian Studies panel "Constructing Buddhist Identities in the West" called for: I was asked to reflect upon "How I as a Western Christian have appropriated Buddhist practice and teachings into my religious identity." (...) I'm grateful for this invitation, because it has provided me with the occasion to realize, quite startlingly, that what I have thought and written about my "Buddhist-Christian identity" in the past really isn't quite accurate.But first let me offer a bird's eye, and therefore limited, view of my two-faced identity: I was born into a traditional, not very critical, Catholic family in the Chicago of seventy-three years ago. At thirteen, I decided (against my parents' wishes) to enter a minor seminary in order to become a priest, and went through the whole fourteen years of training. For the last four years of that training I had the profoundly good fortune to be sent to Rome, arriving there in 1962, two weeks before more than two thousand bishops marched into St. Peter's Basilica to start the Second Vatican Council (the renewing effects of which were much more lasting, it seems, in my psyche than in the psyche and structures of the Vatican!). Ordained a priest in 1966 and animated with Vatican II's new openness to other religions, I did a dissertation at the University of Marburg, Germany, on Christian theologies of religions. When I returned to the United States in 1972, I taught theology at Catholic Theological Union in Chicago, and when I decided to leave the Catholic priesthood in 1975, I moved to Xavier University in Cincinnati, where I continued teaching theology for some twenty-eight years.It was during those years, in the 1980s, that I began not only to teach courses on Buddhism but also to practice daily Zen meditation. Gradually, I came to realize that Buddhism, its theory and practice, was seeping into and coloring the way I understood and practiced my Christian creed—to the point that in 2007 I took refuge in the Tibetan Dzogchen tradition and since then have been under the guidance of my teacher, Lama John Makransky. It was around this time that I faced the need to figure out just what or who I was—a Buddhist Christian or a Christian Buddhist. So, typical academic that I am, I wrote a book. [End Page 19]In Without Buddha I Could Not Be a Christian, I declared and defended my primary identity as a Christian who was thoroughly drenched in Buddhism.1 But when I recently read Rose Drew's penetrating analysis of various ways of blending dual religious belonging in her Christian or Buddhist? An Exploration of Dual Religious Belonging, I started to wonder.2 From her ethnographic study of actual dual belongers, she found that (a) some have a primary religious identity (the group to which I thought I belonged), (b) some alternate between both primary identities, (c) some cannot attribute primacy to either or any identity, and (d) some are too bewildered by it all to say anything.3 As I pondered Drew's description and analysis of her interviewees' meanderings back and forth across religious lines, I had to admit that I wasn't sure where I belonged. So when the request for this paper came along, I saw it as an opportunity to help myself sort things out.An Inappropriate AnalogyMy problem is that as my Christian and Buddhist practices have continued over these recent five to ten years, more and more, I cannot keep them apart. They remain clearly distinct, but unlike Roger Corless, of blessed memory, I have not been able to honor their distinct identities by practicing them, as Roger apparently did, separately: being a Buddhist from Monday to Thursday, and a Christian from Friday to Sunday (and then waiting to see what would happen). Rather, for me, when I am at Mass, I hear the words of the Scripture readings or of... (shrink)

There is a rapidly growing interest in the topic of sustainability as it relates to long‐term business performance that optimizes the “triple bottom line”: economic, environmental, and social outcomes. This article articulates a multilevel conceptual model for executing a business strategy for sustainability primarily through the design and implementation of human resource management practices. The model builds on open systems theory, the resource based view of the firm, and the concept of line of sight to identify certain key organizational capabilities, (...) group competencies, and individual abilities and other characteristics that combine to drive organizational performance when pursuing a sustainability strategy. The article concludes with a discussion of implications of the model for theory, research, and practice. (shrink)

In chapter 3 of Individuals, entitled ‘Persons’, Strawson argues against dualism and the no-ownership theory, and proposes instead that our concept of a person is a primitive concept. In this paper, it is argued that the basic questions that frame Strawson’s discussion, and some of his main arguments and claims, are dubious. A general diagnosis of the source of these problems is proposed. It is argued that despite these problems Strawson gives an accurate and very insightful description of the way (...) we think about ourselves, which should form the starting point for more speculative accounts of ourselves. (shrink)

A topological model of elementary semiotic schemes is presented. Implications are discussed with respect to the establishment of abstract terms and the search for ultimate meaning.

One afternoon in 1836 the Transcendental Club held its first meeting in Boston. The membership was noteworthy not only for the list of impressive personages, headed by Emerson, but for the general youthfulness of the group (Thoreau was only twenty-two) and for the fact (unusual for the day) that several women were invited to attend. The club consisted mainly of "bright young Unitarians seeking to find meaning, pattern, and purpose in a universe no longer managed by a genteel and amiable (...) Unitarian God." The club met irregularly for three years and then passed into oblivion. The intellectual activity it engendered continues to affect American thought and values even today. The transcendentalists concerned themselves with problems of law, truth, individuality, theology, mysticism, pantheism, and personality, to mention only a few. Moreover, they were prolific writers and produced reams of letters, essays, poems, sketches, and memoirs. Historian Paul Boller traces the movement from its earliest stirrings through its height as a powerful movement to its decline in the aftermath of the Civil War. Whenever possible, he lets the transcendentalists speak for themselves. He sorts the permanent from the transient and demonstrates the immeasurable importance of a body of ideas which still live a century and a half after their inception.--From publisher description. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Comparative Theology Is Not “Business-as-Usual Theology”:Personal Witness from a Buddhist ChristianPaul F. KnitterThe following reflections find their stimulus and start in a paper prepared for a doctoral seminar on comparative theology led by John Makransky at Boston College. I was asked whether I was a comparative theologian and, if so, what difference it had made in my professional work as a theologian and in my personal life as a (...) Christian. My basic answer was: “Yes, I think so” and “A lot!”In this reworking and expansion of that seminar paper, I hope to unpack that “a lot.” This will enable me not only to carry on the search for clarity (and integrity) that I began in my book Without Buddha I Could Not Be a Christian,1 but also to comment on the promise of comparative theology (CT) and why I fear that this promise all too often goes unfulfilled.What I’m getting at is capsulized in a blurb that John Thatamanil wrote for Michelle Voss Roberts’s Dualities: A Theology of Difference:2 “Comparative theology done well is a dangerous discipline precisely because it raises provocative questions and threatens to put an end to business-as-usual theology.” I fear that some comparative theologians are not taking their job seriously enough—or they are not following through with what they say they want to do. They are carrying on CT as business as usual.moving beyond business-as-usual theologyComparative theology, which two decades ago might have been considered a fade but has become a fixture in Christian theology,3 makes the bold, indeed thoroughly revolutionary, claim that in order to properly carry on the task of Christian theology, the traditional Christian sources—Scripture, tradition, the lex orandi or spiritual practice of the communities—are not enough. A Christian theologian, in order to be a Christian theologian, must also draw on the experience, teachings, scriptures, and insights of other spiritual communities and traditions. CT embodies Raimon Panikkar’s often [End Page 181] cited (at least by me!) dictum: In order to understand who I am, I have to ask who you are. And in order to know my God I have to ask about your God.4If what comparative theologians are here claiming is true, if my understanding of myself is incomplete without my understanding of you, then after I understand you, I can be pretty sure that my understanding of myself is going to be different—really different. Otherwise, I really didn’t need to talk with you in the first place! And this is why Thatamanil can rightly sound his unsettling warning that if CT is another form of business-as-usual theology, if it is not leading to some really new discoveries about oneself and one’s own tradition, then it is not living up to its job description. And that, as I tried to say elsewhere, is what I suspect might be the case.As I survey the output of comparative theologians over the past fifteen years, I sense that, with some promising exceptions among younger scholars, they are strong on comparing but soft on concluding. More pointedly, comparative theology, so far, has been more comparison than theology. There have been intricate comparisons of Christian texts with Hindu texts and of Christian theologians/mystics with Buddhist scholars/mystics. Striking similarities and stark differences have been noted and examined, sometime meticulously. But, where are the clear, creative, courageous conclusions as to what Christians can learn from these comparisons? What might need to be clarified or changed or discarded in traditional Christian doctrine? Especially on the neuralgic and politically dangerous (for Catholics) issue of the uniqueness of Christ, I am not aware of any comparativists who have learned anything new. I would be delighted to be proved wrong.5I suspect that the reason why some comparative theologians are caught in business-as-usual theology is that they are also still lingering under the influence of postmodernism’s and postliberal theology’s insistence on the dominance of diversity. In their concern to respect and defend differences, postmodernists and postliberals conclude that cultures and religions are more different than they... (shrink)